Abstract: Objective To study the correlation between serum uric acid（UA） and total bilirubin（TBIL） levels and coronary atherosclerotic plaques. Methods Two hundred and ninety-two patients selected from 300 patients with atherosclerotic coronary heart disease（CHD） who underwent twice of coronary angiography in our hospital from January 2009 to November 2012 were divided into progressive atherosclerotic plaque group（n=183） and non-progressive atherosclerotic plaque group（n=109） according to their quantitative coronary angiography（QCA）.Correlation between their serum UA and TBIL levels and their coronary atherosclerotic plaques was analyzed. Results The serum UA and TBIL levels were significantly higher in progressive atherosclerotic plaque group than in non-progressive atherosclerotic plaque group（337.02±45.26 vs 291.47±53.6,P=0.025;13.08±1.94 vs 10.96±1.73,P=0.03）. Conclusion Higher serum UA level and lower serum TBIL level are correlated with the occurrence and severity of CHD,and can thus be used as a predictor for its early prevention,diagnosis and prognosis.