加德纳菌与细菌性阴道病的相关性

Correlation between Gardnerella vaginalis and bacterial vaginitis

  • 摘要: 目的 探讨加德纳菌 (Gardnerella vaginalis, GV) 与女性细菌性阴道疾病 (bacterial vaginitis, BV) 的相关性。 方法 选取2012年1月-2013年6月在本门诊就诊的212例阴道炎患者为研究对象 (观察组), 同时选取200例行妇科检查的正常体检者为对照组, 对两组患者阴道分泌物进行GV鉴定及药敏试验, 分析引起GV感染的高危因素。 结果 观察组GV培养、线索细胞检测、BV试验阳性率均高于对照组 (P<0.05) 。经药敏试验发现GV对万古霉素、痢特灵、菌必治的敏感性较高 (P<0.05) 。经Logistic多因素分析可知, 初次性交年龄过低、有流产史、节育器避孕、年龄>30岁是引起GV感染的独立危险因素。 结论 加德纳菌感染与细菌性阴道病存在密切关系, 临床应对高危感染人群加强防治, 减少BV的发生。

     

    Abstract: Objective To study the correlation between Gardnerella vaginalis(GV) and bacterial vaginitis(BV). Methods Two hundred and twelve vaginitis patients admitted to our outpatient department from January 2012 to June 2013 served as a study group and 200 females undergoing gynecological examination served as a control group in this study.GV was identified by analyzing their vagina secretions and its drug sensitivity was tested.High risk factors for GV infection were analyzed. Results The positive rates of GV culture,clue cell detection and BV test were higher in study group than in control group(P<0.05).Drug sensitivity test showed that GV was sensitive to vancomycin,furazolidone,and ceftriaxone(P<0.05).Multivariate logistic analysis displayed that young age at the first intercourse,history of abortion,contraceptive device,age ≥30 years were the independent risk factors for GV infection. Conclusion GV infection is closely related with bacterial vaginitis,GV infection should thus be prevented and controlled in its high risk populations.

     

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