IL-6和IL-10基因多态性与睡眠呼吸暂停综合征合并高血压的关系
Relation between IL-6 and IL-10 polymorphism and OSAHS accompanying hypertension
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摘要: 目的 探讨IL-6和IL-10基因多态性与阻塞性睡眠呼吸暂停综合征 (obstructive sleep apnea hypoventilation syndrom, OSAHS) 合并高血压的关系。 方法 选择2006-2012年于本院行多导睡眠检查为重度OSAHS的男性患者300例, 其中合并高血压者145例, 单纯OSAHS155例, 同时随机抽取100例健康男性为对照组, 采用基因测序的方法, 检测IL-6启动区基因-572C＞G和-174C＞A, 以及IL-10启动区基因-592A＞C和-1082C＞A的基因多态性。比较OSAHS伴高血压组、单纯OSAHS组以及健康对照组之间IL-6和IL-10基因多态性的关系。 结果 IL-6-572的GG型基因在OSAHS合并高血压组比例增高, 为11.0%, 而单纯OSAHS组为4.1%;IL-6-174的CG型基因在OSAHS合并高血压组明显增高, 为6.2%, 而单纯OSAHS组为0.6%;IL-6-174的C等位基因频率在OSAHS合并高血压组也明显增高, 为3.1%, 而单纯OSAHS组为0.3%;IL-10-1082的AG型基因在OSAHS合并高血压组明显增高, 为20.7%, 而单纯OSAHS组为11.0%;IL-10-1082的G等位基因频率也明显增高, 为10.4%, 而单纯OSAHS组为5.5%;IL-10-592A/C的基因类型在各组之间的基因频率分布差异无统计学意义。 结论 IL-6-572GG型基因、IL-6-174CG型基因和IL-10-1082AG型基因可能参与OSAHS相关高血压的发病。Abstract: Objective To study the relation between IL-6 and IL-10 polymorphism and OSAHS accompanying hypertension. Methods Three hundred severe male OSAHS patients（145 with OSAHS accompanying hypertension,155 with simple OSAHS） admitted to our hospital from 2006 to 2012 served as an OSAHS group and 100 healthy males served as a control group in this study.Polymorphonisms of IL-6-572C＞G,IL-6-174C＞A,IL-10-592,and IL-10-1082C＞A were detected by gene sequencing.Relation between IL-6 and IL-10 polymorphism was compared in OSAHS accompanying hypertension group,simple OSAHS group and control group. Results The frequencies of IL-6-572 genotype GG,IL-6-174 genotype CG,IL-6-174 allelic gene C,IL-10-1082 genotype AG,and IL-10-1082 allelic gene G were significantly higher in OSAHS accompanying hypertension group than in simple OSAHS group（11.0% vs 4.1%,6.2% vs 0.6%,3.1% vs 0.3%,20.7% vs 11.0%,10.4% vs 5.5%）.However,no significant difference was found in the frequency of genotype A/C of IL-10-592 between the two groups. Conclusion IL-6-572 genotype GG,IL-6-174 genotype CG and IL-10-1082 genotype AG may participate in the occurrence of OSAHS-related hypertension.
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