Abstract: Objective To study the effect of combined atorvastatin and valsartan on chronic nephritis. Methods Sixty chronic nephritis patients admitted to our hospital from June 2010 to December 2012 were randomly divided into observation group and control group (30 in each group). Patients in observation group received combined atorvastatin and valsartan treatment and those in control group received atorvastatin treatment. Their 24 h urinary protein level and serum levels of creatinine, blood urea nitrogen and CRP, and blood pressure were measured and compared before treatment and 20 weeks after treatment. Results The 24 h urinary protein was significantly lower in two groups 20 weeks after treatment than before treatment (P< 0.05) and the curative effect was better in observation group than in control group (P< 0.05). No significant difference was found in serum creatinine and usea nitrogen level between the two groups although they were lower after treatment than before treatment (P> 0.05). The blood pressure was significantly lower in two groups after treatment than before treatment (P< 0.05) and the curative effect was better in observation group than in control group (P< 0.05). No significant difference was found in serum CRP level in control group before and after treatment (P> 0.05) although the curative effect was better in observation group than in control group (P< 0.05). Conclusion Combined atorvastatin and valsartan can decrease the blood urinary protein level, blood pressure and serum CRP level in chronic nephritis patients and is thus worthy of application in clinical practice.