阿托伐他汀对衰老大鼠多器官氧化应激指标的影响

张今尧; 叶平; 王浩; 韩磊

doi:10.3969/j.issn.2095-5227.2014.04.014

阿托伐他汀对衰老大鼠多器官氧化应激指标的影响

Effect of atorvastatin on multiple organ oxidative stress in aging rats

摘要

摘要: 目的观察大鼠衰老后心、肝、肾多器官氧化应激指标的变化以及阿托伐他汀在此过程中的作用。方法 10月龄大鼠饲养至20月龄，随机分为大剂量他汀组、小剂量他汀组，分别予阿托伐他汀10 mg/（kg·d）和1 mg/（kg·d）灌胃处理，并设立老年对照组及青年对照组。检测血清内超氧化物歧化酶、丙二醛、过氧化氢酶、一氧化氮合成酶含量，并检测心脏、肝、肾各器官内超氧化物歧化酶、丙二醛、过氧化氢酶、一氧化氮合成酶、脂褐素含量。结果与老年对照组相比，青年对照组及大剂量他汀组血清中过氧化氢酶、过氧化物歧化酶、一氧化氮合酶均显著升高（P<0.01），丙二醛显著降低（P<0.01）。与老年对照组相比，大剂量他汀组中心脏、肝、肾多器官中过氧化氢酶、超氧化物歧化酶、一氧化氮合酶均显著升高（P<0.01）；丙二醛、脂褐素显著降低（P<0.01）。结论大鼠衰老后，血清及心脏、肝、肾多器官内氧化应激水平增强，阿托伐他汀可抑制此变化。

Abstract: Objective To study the effect of atorvastatin on multiple organ oxidative stress, such as heart, liver and kidney, in aging rats. Methods Twenty months old rats were randomly divided into high statin dose (10 mg/kg · d) group, low statin dose (1 mg/kg · d) group, elderly control group and young control group. Their serum levels of SOD, MDA, CAT, NOS and LPF were measured. Results The serum levels of CAT, SOD and NOS were significantly higher whereas those of MDA and LPF were significantly lower in young control group and high statin dose group than in elderly control group and low statin dose group (P< 0.01). Conclusion Atorvastatin can inhibit the exaggerated multiple organ oxidative stress such as heart, liver and kidney, in aging rats.

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