Abstract: Objective To assess the short- and long-term effect of endoscopic chemotherapeutic slow-releasing ion implantation on carcinomatous obstruction in upper digestive tract. Methods Of the 7 patients with advanced cancer admitted to our hospital from March 2008 to May 2013 for endoscopic implantation of chemotherapeutic slow-releasing ions into their carcinomatous obstruction and infiltration sites, 3 who were diagnosed was gastric cancer underwent 5-FU ion (148 mg) implantation and 4 who were diagnosed with esophagus cancer patients underwent cisplatin ion (48 mg) implantation. Results Seven patients received 9 times of slow-releasing ion implantation, during which no hemorrhage or perforation occurred, and their hepatic and renal function and blood routine examination were normal. The therapeutic effect endoscopic chemotherapeutic slow-releasing ion implantation was very significant in 1 patient, significant in 3 patients, good in 2 patients and poor in 1 patient, with a total efficiency of 85.7%. The average sustained symptom-relieving time was 20 days after once of treatment. Of the 7 patients, 6 died with a survival time of 2-8 months (mean 112 days). Conclusion Endoscopic chemotherapeutic slow-releasing ion implantation is a choice of treatment for carcinomatous obstruction in patients with advanced upper gastric cancer.