Abstract: Objective To summarize the experiences of early diagnosis and treatment of epilepsy induced by glioma. Methods Clinical data (including gender, age, clinical symotom, imaging findings and pathological categories) of patients who enrolled in our department from August 2011 to July 2012 and underwent resection of glioma were retrospectively analyzed. Results Of the 207 glioma patients in this series, 63 (30.4%, male 39, female 24, with the age of 15-65 (mean, 40.11±11.33) years) presented with seizures. There was no sex predominance (P> 0.05). Generalized tonoclonic seizure was the main form of attack (35, 55.6%). Factors more commonly associated with preoperative seizures were frontal lobe (45, 71.4%), involvement and cortical location (59, 93.7%), and low grade glioma pathology (37, 58.7%). Surgery followed by radiation and chemotherapy could control epilepsy effectively. Conclusion Patients with epilepsies induced by glioma are advised to be treated with surgery combined with radiotherapy and chemotherapy.