胃癌和贲门癌患者外周血表皮生长因子和瘦素水平变化及临床意义

廖杰; 邓子辉; 王录焕; 张金英; 薛辉

doi:10.3969/j.issn.2095-5227.2014.08.021

胃癌和贲门癌患者外周血表皮生长因子和瘦素水平变化及临床意义

Clinical significance of epidermal growth factor and leptin levels changes in the serum in patients with gastric carcinoma and carcinoma of cardia

摘要

摘要: 目的探讨胃癌和贲门癌患者外周血表皮生长因子(epidermal growth factor，EGF)和瘦素(Leptin)水平变化及与肿瘤标记物甲胎蛋白(alpha-fetoprotein，AFP)水平之间的关系。方法收集我院2012年10月- 2013年1月健康查体的工作人员及确诊胃癌和贲门癌患者的血清，放射免疫分析法检测150例胃癌患者、50例贲门癌患者、50例健康人员血清EGF、Leptin、AFP水平。结果胃癌及贲门癌患者血清EGF、Leptin、AFP水平均显著高于正常对照组(P均< 0.01)，直线相关分析发现，EGF与胃癌患者AFP水平显著正相关(r=0.291 2，P< 0.01)，其余检测指标间无显著相关性。结论胃癌及贲门癌患者血清均存在高水平的EGF和Leptin，但两者之间无相关性，各自独立发挥作用；血清EGF水平和AFP显著正相关，两者联合可能有助于胃癌诊断。

Abstract: Objective To exp lore the EGF and leptin levels changes and their relationship with AFP level in patients with gastric carcinoma or carcinoma of cardia． Methods Serum from normal control and patients with gastric carcinoma or carcinoma of cardia in our hospital from October 2012 to January 2013 were collected． EGF, leptin, and AFP levels were detected by Radio-immunoassay in serum of 150 gastric carcinoma patients, 50 carcinoma of cardia patients and 50 normal control． Results The levels of EGF, leptin and AFP were signif cantly higher in serum of gastric carcinoma and carcinoma of gastric cardia patients than in serum of normal control． In serum of gastric carcinoma patients EGF level had direct correlation with AFP level (r=0．291 2, P< 0．01) by correlation analysis while other markers had no relationship． Conclusion EGF and leptin levels are higher in serum of gastric carcinoma and carcinoma of cardia patients than in serum of normal control, EGF and Leptin have no relationship in patients’ serum, but EGF and AFP are signif cant to diagnose gastric carcinoma．

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