Abstract: Objective To explore the correlation between Xeroderma pigmenting group D (XPD)gene polymorphisms and non-Hodgkin lymphoma (NHL) risk． Methods A case-control study with 282 non-Hodgkin lymphoma patients and 231 control subjects were conducted to investigate the role of two XPD gene polymorphisms (rs1799793, rs13181) on susceptibility to non-Hodgkin lymphoma by SNaPshot． A ll statistical analysis were done with R software． Genotype and allele frequencies of XPD were compared between patients and control group by chi-square test． Crude and adjusted odds ratios and 95% conf dence intervals were calculated by logistic regression based on genetic different models． Results There was no signif cant difference between the control group and NHL or NHL subtype cases in genotype and variant genotype frequency． Analysis of XPD rs1799793, rs13181 showed that no combined genotype was associated with risk of NHL overall or four kinds of subtypes of NHL． Conclusion There is no close relationship between XPD polymorphism (rs1799793, rs13181) and the risk of NHL or each histologic subtype of NHL．