体质量指数对移植肾功能的影响

Effects of BMI on graft function after kidney transplantation

  • 摘要: 目的 研究体质量指数(body mass index,BMI)对肾移植术后移植肾功能的影响。 方法 回顾2008年1月-2011年12月本院肾移植受者238例临床资料,根据术前BMI分为3组:BMI< 24.9 kg/m2(正常组,A组),BMI 25~29.9 kg/m2(超重组,B组),BMI≥30 kg/m2(肥胖组,C组)。对比3组术后移植肾功能延迟恢复(delayed graft function,DGF)的发生率、术后1年内急性排斥反应(acute rejection,AR)发生率、血肌酐恢复至正常水平所需时间。 结果 肾移植术后DGF发生率A组为20.93%,B组为21.74%,C组为55%(P< 0.01)。急性排斥发生率A组为12.79%,B组为16.30%,C组为43.33%(P=0.088)。血肌酐恢复至正常水平所需时间A组为(7.65±3.23) d,B组为(6.99±5.36) d,C组为(11.45±6.20) d (P< 0.01)。 结论 体型肥胖肾移植受者术后DGF的发生率较高,术后血肌酐恢复至正常水平所需时间更长。

     

    Abstract: Objective To compare and analyze the effects of body mass index (BMI) levels on graft function after kidney transplantation. Methods Clinical data about 238 renal transplant recipients admitted to our hospital from January 2008 to December 2011 were retrospectively analyzed. Recipients were divided into three groups based on BMI at the time of transplantation: group A (BMI< 24.9 kg/m2), group B (BMI 25-29.9 kg/m2) and group C (BMI≥30 kg/m2). The comparative analysis included onset of delayed graft function (DGF), acute rejection episodes and time of serum creatinine recovery to normal. Results DGF occurred more frequently in group C (55%) than in group A (20.93%) and group B(21.74%) (P< 0.01). No significant differences of acute rejection episodes were found among the three groups with 12.79% in group A, 16.30% in group B and 43.33% in group C (P=0.088). Time of serum creatinine recovery to normal was 7.65±3.23 days in group A, 6.99±5.36 days in group B and 11.45±6.20 days in group C (P< 0.01). Conclusion Obese recipients (BMI≥30 kg/m2) are suffered to more incidence of DGF and longer time of serum creatinine recovery to normal than non-obese recipients.

     

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