Abstract: Objective To assess the evaluation of preoperative ultrasonography with optic disk depression in patients with severe chemical injury. Methods Clinical data about 28 patients (28 eyes) with chemical burns in the eyes with severe tissue damage and prepared to undergo the arti ficial cornea transplant (Boston Ⅰ) in our hospital from January 2010 to June 2013 were retrospectively analyzed. The preoperative examination was performed in 28 eyes using Flash Visual Evoked Potentia (F-VEP) and B-scan ultrasonography, respectively. The results were divided into optic disc depression and non optic disc depression according to the eyeball wall morphology, and all patients had undergone the artificial cornea transplant (Boston Ⅰ). The images and data were analyzed and compared with the operation results. Results In 28 cases, there were 5 cases of optic disc depression, and the best corrected visual acuity of postoperative were 0.05 in 1 case, 0.1 in 1 case, 0.12 in 1 case, finger count/1 m in 2 cases. Preoperative ultrasonic diagnosis without optic disc occurred in 23 cases, the best corrected visual acuity of postoperative ranged from 0.1- 0.8 (0.5±0.36). Conclusion The B-scan ultrasonography can observe the prognostic visual accurately by optic disk depression in patients with chemical burns eyes.