Abstract: Objective To study the factors infuencing the scores of Clinical Epidemiology of the master postgraduate in a medical college and provide theoretical basis and reference for clinical epidemiology education. Methods Three hundred and thirty-six master postgraduate of 2013 in Chinese PLA Medical School were enrolled in this study. Their study attitude towards clinical epidemiology and their achievements were investigated through data collected from the questionnaire, and the factors infuencing the learning effect were analyzed using the multivariate linear regression. Results The students generally showed a strong interest and a high level of attention in Clinical Epidemiology with 80 percent of them had already heard of and known this course before learning. There showed positive correlation between age, gender, emphasis on the course, undergraduate studied related courses and scores of clinical epidemiology, and negative correlation between part-time students, previous work experience and scores of clinical epidemiology. Conclusion The learning effect will be better with the improvement of the emphasis on this course, and the part-time students should be aware of the allocation of time and make efforts to narrow the gap between traditional ones.