Abstract: Hypoxia is a common phenomenon in solid tumor, and hypoxia inducible factor (HIF) is a key transcription factor in the process of transmitting and mediating anoxic singals. Epithelial mesenchymal transitions (EMT) is a multi-step, ordered and highadjusted process, which palys an important role in tumor invasion and involves in various proteins, microenvironment, MicroRNA, signal pathway and molecular mechanism. Studies prove that hypoxia can regulate EMT through signal pathway of TGF-β, Notch, Wnt, Hedgehog and HGF/Met. Studies about blocking EMT through inhibition of HIF are effective, which indicates that HIF-induced EMT may be a new target of tumor therapy, and this means a lot to the prevention and therapy of cancer.