肿瘤坏死因子抑制剂治疗放射学阴性中轴性脊柱关节炎的新进展

Advances in TNF inhibitors therapy in patients with radiographic negative axial spondyloarthritis

摘要: 肿瘤坏死因子(tumor necrosis factor，TNF)抑制剂在强直性脊柱炎(ankylosing spondylitis，AS)患者中已有明确疗效。为了更好地随访具有AS潜在风险的患者，有学者提出放射学阴性脊柱关节炎(axial nonradiographic spondyloarthritis，nraxSpA)这一概念。近年来越来越多的研究旨在探究TNF抑制剂对nr-axSpA患者的早期疗效。研究发现，TNF抑制剂治疗nr-axSpA的疗效至少与AS相同，甚至很有可能优于AS，并且治疗越早治疗反应越好。本文对TNF抑制剂治疗放射学阴性中轴性脊柱关节炎的新进展进行综述。

Abstract: The tumor necrosis factor (TNF) inhibitors are very effective in treating ankylosing spondylitis (AS). For a better followup patients with a potential risk of AS, some scholars have proposed the concept of axial nonradiographic spondyloarthritis (nraxSpA). In recent years, more trials are focusing on early treatment of TNF inhibitors in patients with nr-axSpA. Researches show that compared with AS, TNF inhibitors are as effective in patients with nr-axSpA at least and maybe even more effective when patients with nr-axSpA are treated earlier. The focus of this review is to discuss the advances in TNF inhibitors therapy in patients with nr-axSpA.