Abstract: Objective To analyze the clinicopathological features and prognosis of colorectal cancer with high lactate dehydrogenase (LDH) level retrospectively. Methods Clinical pathological and prognosis data about 112 cases patients with colorectal cancer in our hospital from January 2007 to July 2012 were collected. According to the LDH level, patients were divided into high LDH and low LDH groups. The differences of clinicopathological features and prognosis between the two groups were analyzed. Results There were significant differences in T stage (χ²=8.210, P=0.016) and CEA level (χ²=6.946, P=0.008) between two groups. Univariate analysis showed that LDH level (χ²=10.312, P=0.001), T stage (χ²=17.141, P< 0.01), M stage (χ²=11.830, P< 0.01) and CEA level (χ²=6.381, P=0.012) were positively correlated with survival. The 1, 3, 5-year survival rate of high LDH group and low LDH group were 81.5%, 49.4%, 42.1% and 92.7%, 79.4%, 66.2%, respectively. The multivariate analysis showed that LDH level (HR=2.236, P=0.016) and T stage (HR=2.299, P=0.012) were independent prognostic factors for survival. Conclusion Colorectal cancer patients with high serum LDH level have poor prognosis.