Abstract: Objective To explore the clinical risk factors in patients with premature coronary heart disease (PCHD) accompanying diabetes mellitus (DM) and investigate the early and intermediate effect and safety of implanted drug-eluting stents. Methods Five hundred and fifty-one patients who underwent drug-eluting stenting in our department from January 2009 to December 2012 were divided into PCHD with DM group (n=236) (follow-up 228, 96.6%) and PCHD without DM group (n=315) (follow-up 300, 95.3%) based on whether suffering from DM or not. The early and intermediate major adverse cardiac events (MACE) in patients after drug-eluting stenting were studied. Results The ratio of hypertension (71.1% vs 59.3%, P=0.049), the proportion of female patients (39.5% vs 26%, P=0.02) and the average age (52.36±7.42 vs 50.29±6.84, P=0.02) in PCHD complicated with diabetes mellitus group were higher than non-diabetic group, smoking (33.3% vs 46%, P=0.038) ratio was less than non-diabetic group. Incidence of MACE had no statistical significance between the two groups (P> 0.05), but the MACE incident rate were higher than non-diabetic group. Conclusion Comparing with non-diabetic patients, diabetic patients presenting with PCHD treated with DES have the same occurrence rate of MACE during short-term follow-up. Further large and multicenter follow-up studies are still required.