Abstract: Objective To compare the clinical efficacy of partial-cystectomy with 2-micron laser and transurethral electroresection in T1G3 bladder cancer and investigate the technique advantages of partial-cystectomy with 2-micron laser treatment. Methods Of the 49 patients with T1G3 bladder cancer in our hospital from January 2009 to December 2013, 23 cases were treated by partialcystectomy with 2-micron laser and 26 cases were treated by transurethral electroresection. Their intraoperative and postoperative complications, positive rate and postoperative recurrence were analyzed. Results Obturator nerve reflex occurred in 6 cases and bladder perforation in 2 cases in the transurethral electroresection group, hemoturia and severe irritation sign of bladder were also found in the transurethral electroresection group, which were obviously more than that in partial-cystectomy with 2-micron laser group (P< 0.05). In partial-cystectomy with 2-micron laser group, all cases were negative for second-biopsy, and the positive rate of second-biopsy in transurethral electroresection group was 23.1% (6/26). The total tumor recurrence rate of partial-cystectomy with 2-micron laser group was obviously lower than transurethral electroresection group (P< 0.05). Conclusion The complication of partial-cystectomy with 2-micron laser group is significantly less than that of transurethral electroresection group. Partial-cystectomy with 2-micron laser is a safe and efficient procedure for the treatment of T1G3 bladder cancer.