妊娠期急性脂肪肝16例诊疗分析

Diagnosis and treatment of acute fatty liver during pregnancy: A report of 16 cases

摘要: 目的探讨妊娠期急性脂肪肝（acute fatty liver of pregnancy，AFLP）的临床诊疗及预后。方法回顾性分析2009年12月-2014年7月本院收治的16例AFLP临床资料。结果 16例发病孕周30⁺⁵～ 40⁺²（35.2±2.7）周，经保肝、补充凝血因子、手术等综合治疗，14例好转出院，2例出院后死亡，在我院分娩新生儿14例，死亡1例。结论早期诊断、及时终止妊娠、多学科合作、综合治疗是改善孕产妇及新生儿预后的关键。

Abstract: Objective To study the clinical diagnosis, treatment and prognosis of acute fatty liver during pregnancy (AFLP). Methods Clinical data about 16 AFLP patients admitted to our hospital from December 2009 to July 2014 were retrospectively analyzed. Results The mean maternal age of 16 AFLP patients were 35.2±2.7 weeks (range, 30⁺⁵- 40⁺²weeks), after the treatment of liver-protective drugs, coagulation factors and surgery, 14 cases survived and 2 died after discharged. 14 newborns were born in our hospital and 1 case died. Conclusion Early diagnosis, timely termination of pregnancy, multidisciplinary collaboration and combined treatment are important in ensuring a successful maternal and fetal outcome.