Abstract: Objective To explore the interventional treatment methods in nonanastomotic biliary strictures after orthotopic liver transplantation and observe the effectiveness. Methods Clinical data about 9 cases with nonanastomotic biliary strictures after liver transplantation from January 2009 to December 2013 in the 309th Hospital of Chinese PLA were retrospectively analyzed and balloon dilatation and drainage were performed through axillary midline approach and xiphoid process in 9 cases. Results Of the 9 cases characterized by multiple narrow intrahepatic bile ducts merging with bile mud formation, 2 cases had anastomotic stenosis and 1 case had anastomotic fistula. The treatment in 2 cases was invalid with progressive jaundice index and no obviously alleviated clinical symptoms and signs were found. While, the treatment in the other 7 cases was effective with decreased jaundice index and obviously alleviated clinical symptoms and signs. Conclusion Repeated balloon dilatation, biliary drainage of branches several times and repeated biliary shaping are effective methods for nonanastomotic biliary strictures.