Abstract: Objective To discuss the clinical effect of adult degenerative scoliosis (DS) treated with expansive pedicle screws (EPS). Methods Clinical data about 21 cases with DS who underwent orthopaedic operation by EPS in our hospital from January 2012 to September 2013, including 4 males and 17 females with an average age of 60.1 years (range from 45-74 years), were retrospectively analyzed. The spinal length X-ray films were taken at pre-operative, 5-7 d and 1 year after operation, and imaging parameters were recorded. The scores of lumbago and skelalgia of VAS and ODI were collected. Results All cases were followed up for more than 1 year. 252 EPSs were used, and 5 screws were pulled out. The comparison of Cobb angle, C7-CSVL, LL, PT, SS, SVA of pre-operative and pro-operative had statistical significance (P< 0.05). The lumbago and skelalgia of VAS and ODI scores of pre-operative and pro-operative were (6.2±2.2, 3.8±1.5), (5.3±2.7, 3.3±2.3), (35.3±6.4, 17.6±7.3), respectively, which had statistical significance (P< 0.05). The orthopaedic effect was excellent. Conclusion Application of expandable pedicle screws in treatment of degenerative scoliosis can obtain good clinical efficacy.