Abstract: Objective To discuss the risk factors of secondary contralateral fractures among elderly hip fracture patient, and compare the effect of nursing intervention on secondary contralateral fractures after hip fracture surgery. Methods Patients with fracture over 60 years from January 2012 to December 2012 in our hospital, excluding patients with bilateral fractures, previous fractures, pathologic fractures and multiple trauma, were enrolled in this study. They were randomly divided into intervention group and control group. After 1 year of surgery, the differences of the rate of secondary contralateral hip fractures and physical functional between two groups were compared. Results A total of 386 patients met the inclusion criteria, and they were randomly assigned to the intervention group (n=193) and control group (n=193). There were no significant differences in age, gender, body mass index, comorbidities, type of surgery between two groups. 12 cases (6.2%) in intervention group and 20 cases (10.4%) in control group lost follow-up. Follow-up results showed that 6 cases (3.1%) had secondary contralateral hip fractures in the intervention group, 15 cases (8.7%) in the control group. Anti-fall comprehensive intervention significantly reduced the rate of the secondary contralateral hip fractures (P=0.033). Simultaneously, one year after the surgery, the function rehabilitation in intervention group were significantly better than the control group (75.1 vs 69.4, P=0.000). Multivariate analysis showed that severe osteoporosis, nervous system diseases, respiratory diseases, cardiovascular diseases were the main risk factors for secondary contralateral fractures among elderly hip fracture patient. Conclusion Comprehensive nursing intervention can effectively reduce rate of secondary contralateral fractures after hip fracture surgery.