Abstract: Objective Toobserve the efficacy and safety of 1-site versus 2-site phacotrabeculectomy in eyes coexisting with cataract and glaucoma. Methods Rand omizedcontrolledtrials about one-site versus two-site trabiculectomy with a minimumfollow-upof 12 months were searchedfromJanuary 1, 1998 toDecember 31, 2014 in database of PUBMED, EMBASE, Cochrane Library, CNKI, CNVIP, WANFANG DATA. Articles uptothe stand ardwere reviewedand selectedand data were analyzed. The effectiveness was definedas intraocular pressure (IOP), number of antiglaucoma medication, and safety was definedas adverse events, intraocular posterior capsular rupture, postoperative hyphema, intraocular hypotension, conjuntival/bleb leakage, shallowanterior chamber, choidal effusion/detachment, posterior capsular opacification/laser capsulotomy. Results Five articles were includedin this metaanalysis. There were nodifferences in postoperative intraocular pressure (I²=46%, P=0.08) and antiglaucoma medication (I²=0, P=0.10) between 1-site group(n=251) and 2-site group(n=252), or in intraocular posterior capsular rupture, postoperative hyphema, intraocular hypotension, conjuntival/bleb leakage, shallowanterior chamber, choidal effusion/detachment, posterior capsular opacification/laser capsulotomy (P＞ 0.05). Visual acuity was better postoperatively than preoperatively in twogroups. Onesite surgery was less time-consuming (I²=95%, P=0.000 6). Conclusion There are nodifferences between one-site and two-site phacotrabeculectomy in termof efficacy and safety after a minimumfollow-upof twelve months.