Abstract: Objective To analyze curative effect of comprehensive nursing intervention on patients with irritable bowel syndrome. Methods From April 2012 to December 2014, 120 patients with irritable bowel syndrome in our hospital were chosen as research objects and they were randomly divided into two groups: observation group (n=60) and control group (n=60). Patients in two groups underwent medication combined with comprehensive nursing intervention and routine nursing, respectively. And they were asked to complete self-rating anxiety scale and self-rating depression scale, knowledge questionnaire of irritable bowel syndrome before and 8 weeks after treatment, and their clinical symptoms were collected to observe the curative effect. Results After treatment, the curative effect of observation group was much better than control group (86.67% vs 61.67%, P< 0.05), the anxiety and depression scale score of observation group was significantly lower than control group (42.54±6.04) vs (52.92±6.09), (45.42±5.84) vs (54.88±5.91), P< 0.05. The knowledge questionnaire score of observation group was significantly higher than control group (23.15±3.82) vs (16.76±4.73), P< 0.05. Conclusion Compared with conventional care, comprehensive nursing intervention can improve the curative effect of patients with irritable bowel syndrome.