Abstract: Exosomes are microvesicles derived from the endosomal compartment of cell. An increasing evidence indicates that exosomes play a pivotal role in intercellular information transmission, and they may directly stimulate target cells by receptormediated interactions or transfer various bioactive molecules including membrane receptors, proteins, mRNAs, and microRNAs to target cells. With the advances in technique, more studies are conducted to the clinical applications of exosomes for diagnosis, prognosis, and therapy. The increased understanding of exosomes reveals a very complex contribution of exosomes to health and disease. In this review, we summarize the current progress and clinical application of exosomes．