变应性鼻炎对成人阻塞性睡眠呼吸暂停低通气综合征的影响

Effect of allergic rhinitis on adult obstructive sleep apnea hypopnea syndrome

  • 摘要: 目的 探讨变应性鼻炎(allergic rhinitis,AR)对成人阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的影响。 方法 筛选同时患有持续性AR及OSAHS(除外中枢性OSAHS)成人(年龄> 18岁)共120例,进行血清IgE、变应原检测,鼻内镜、多导睡眠监测(polysomnography,PSG)检查,比较患者系统抗过敏治疗前后鼻部症状评分、呼吸暂停低通气指数(apnea hypopnea index,AHI)、最低血氧饱和度(lowest oxygen saturation,LSaO2)、鼾声指数和嗜睡程度(epworth sleepiness scale,ESS)。 结果 持续性AR伴有轻度OSAHS患者经正规抗过敏治后AHI、LSaO2、ESS评分及鼾声指数分别为(7.74±0.62)次/h、(89.00±0.71)%、6.80±0.59、97.47±13.64,与治疗前(10.68±0.94)次/h、(81.10±0.46)%,8.82±0.66、131.48±19.23相比有显著改善(P< 0.05)。持续性AR伴有中度OSAHS患者经正规抗过敏治疗后AHI、LSaO2、、ESS评分及鼾声指数分别为(15.53±1.83)次/h、(79.00±1.65)%、9.26±0.39、187.42±28.26,与治疗前(21.73±2.78)次/h、(70.60±1.77)%,13.53±1.78、234.39±33.79相比有显著改善(P< 0.05)。持续性AR伴有重度OSAHS患者经抗过敏治疗后ESS评分由20.29±1.57降至14.47±1.04(P=0.037);鼾声指数由治疗前367.96±47.25降至252.54±36.47(P=0.029)。 结论 持续性AR伴OSAHS患者经过系统抗过敏治疗后鼻部症状明显改善;AR可加重OSAHS低通气及呼吸暂停次数,影响患者血氧饱和度,加重其白天嗜睡症状。

     

    Abstract: Objective To investigate the effects of allergic rhinitis (AR) on obstructive sleep apnea hypopnea syndrome (OSAHS)in adult. Methods One hundred and twenty adult patients (> 18 years) with allergic rhinitis and OSAHS were selected. Serum IgE, allergen detection, nasal endoscope, and multi-guided sleep monitoring (PSG) were performed. The anti-allergy treatment of all patients, sleeping parameters including apnea hypopnea index (AHI), snoring index, lowest oxygen saturation (LSaO2) and epworth sleepiness scale (ESS) were compared. Results Compared with pre-treatment, the AHI, LSaO2, ESS and snore index of patients with persistent AR and mild OSAHS after treatment improved significantly (7.74±0.62)/h vs (10.68±0.94)/h, (89.00 ±0.71)%vs (81.10±0.46)%, (6.80±0.59) vs (8.82±0.66), (97.47±13.64) vs (131.48±19.23), P< 0.05. Compared with pre-treatment, the AHI, LSaO2, ESS and snore index of patients with persistent AR and moderate OSAHS after treatment improved significantly(15.53±1.83)/h vs (21.73±2.78)/h, (79.00±1.65)% vs (70.60±1.77)%, (9.26±0.39) vs (13.53±1.78), (187.42±28.26) vs(234.39±33.79), P< 0.05. After treatment, ESS and snoring index of patients with persistent AR and severe OSAHS decreased significantly (20.29±1.57) vs (14.47±1.04), P=0.037; (367.96±47.25) vs (252.54±36.47), P=0.029. Conclusion The nasal symptoms improve significantly after regular anti allergy treatment. AR can increase AHI and affect SaO2 which will cause daytime sleepiness in patients with OSAHS.

     

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