维生素D受体基因BsmⅠ、ApaⅠ和TaqⅠ位点多态性与中国男性骨密度相关性的Meta分析

韩金宝; 王龙; 祖源; 李超

doi:10.3969/j.issn.2095-5227.2015.11.017

维生素D受体基因BsmⅠ、ApaⅠ和TaqⅠ位点多态性与中国男性骨密度相关性的Meta分析

Association between BsmⅠ, ApaⅠand TaqⅠpolymorphisms in VDR gene and bone mineral density: a meta-analysis focused on populations in Chinese men

摘要

摘要: 目的探讨维生素D受体VDR基因(包括BsmⅠ，ApaⅠ，TaqⅠ位点)多态性与中国成年男性骨密度的相关性。方法采用Meta分析方法，通过Pubmed、Embase、Cochrane、中国知网、维普网医学文献搜索引擎检索1990 - 2014年VDR基因BsmⅠ、ApaⅠ、TaqⅠ位点多态性与我国大陆多地区、香港及台湾男性骨密度相关性的研究，评价纳入研究质量，提取有效数据后采用Review Manager 5.1进行Meta分析。选择固定效应模型，计算95%置信区间(95% confidence interval，95% CI)，效应量加权均数(weighted mean difference，WMD)。结果纳入8篇质量评价得分为4 ~ 6的文献，1 934例中国成年男性，VDR基因BsmⅠ、ApaⅠ、TaqⅠ位点多态性与股骨颈、大转子和Ward's三角区骨密度的相关性差异无统计学意义。考虑到地域差异，剔除中国香港和台湾地区，发现中国大陆地区成年男性VDR基因BsmⅠ多态性与股骨颈骨密度存在一定相关性(95% CI为0.030.00，0.06，P=0.03)。结论 VDR基因BsmⅠ、ApaⅠ、TaqⅠ位点的多态性与中国多地区男性骨密度无明显相关性。

Abstract: Objective To explore the associations between vitamin D receptor (VDR) gene polymorphisms (including BsmⅠ, ApaⅠand TaqⅠ) and bone mineral density (BMD) in Chinese men. Methods Databases including PubMed, Embase, Cochrane, CNKI and cqvip were retrieved to identify eligible studies (1990-2014). The quality of the included studies was evaluated and the data were extracted. Review Manager 5.1 was used for meta-analysis. Weighted mean difference (WMD) and 95% confidence intervals were calculated by using fixed-effect model. Results A total of 8 studies were included in this meta-analysis, including 1 934 Chinese adult men. The results of meta-analysis showed that VDR BsmⅠ, ApaⅠ, TaqⅠpolymorphisms were not related to bone mineral density in Chinese men (including men in Taiwan and Hong Kong). Excluded men in Hong Kong and Taiwan analysis indicated that VDR gene BsmⅠpolymorphisms were associated with femoral neck BMD in mainland Chinese men (95%CI: 0.030.00, 0.06, P=0.03). Conclusion The present study shows that VDR BsmⅠ, ApaⅠ, TaqⅠpolymorphisms are not associated with bone mineral density in Chinese men.

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