Abstract: Objective To analyze the efficacy of two different internal fixations for femoral shaft nonunion. Methods From June 2009 to June 2013, 92 cases with femoral shaft fracture bone nonunion were enrolled in our hospital.They were divided into two groups depending on the different methods of internal fixation, interlocking intramedullary nailing group(n=48)and double plate joint with granule bone implant group(n=44).The surgical situation, fracture healing time and functional evaluation of the knee joint were compared between two groups. Results All patients had achieved bone union at last, but in the interlocking intramedullary nail group, the length of the incision, blood loss, operative time, postoperative drainage and healing time were significantly less than those of double plate joint with granule bone implant group(P＜0.05).In the interlocking intramedullary nail group, the postoperative knee function score was significantly higher than that of double plate joint with granule bone implant group(P＜0.05). Conclusion The methods of interlocking intramedullary nail and double plate joint with granule bone implant are effective means for femoral shaft fracture nonunion, but interlocking intramedullary nail has a clear effect, simple operation process, smaller trauma and shorter surgery time.