窄谱中波紫外线两种加量方式治疗银屑病的疗效比较

Two schemes of narrowband ultraviolet B(NB UVB)phototherapy in treatment of psoriasis: A comparative study

  • 摘要: 目的 观察窄谱中波紫外线治疗银屑病的两种加量方式的疗效。 方法 根据随机、对照、盲法的原则,将2014年10月-2015年3月解放军总医院皮肤科门诊患者63例随机分为试验组(比率加量法)和对照组(固定剂量加量法),试验组33例,其中男性23例,女性10例;对照组30例,其中男性23例,女性7例。试验组与对照组平均年龄、性别构成、治疗前银屑病面积与严重性指数(psoriasis area and severity index,PASI)评分均无统计学差异。分别按照比率加量法和固定剂量加量法进行窄谱中波紫外线治疗。 结果 3周时试验组PASI评分(5.00±1.275),对照组PASI评分(5.47±1.479),两组疗效差异无统计学意义;5周时试验组PASI评分(1.73±1.626),对照组PASI评分(2.67±1.322),试验组PASI评分改善情况及疗效优于对照组。 结论 在窄谱中波紫外线治疗银屑病的加量方式中,比率加量法具有显效快的特点,可作为首选治疗方案。

     

    Abstract: Objective To find out the differences of the curative effect for psoriasis between percentage dose schemes and fixed dose schemes in narrowband ultraviolet B(NB UVB)phototherapy. Methods From October 2014 to March 2015, according to the principle of randomization, control and blindness, 63 patients admitted to Chinese PLA General Hospital were divided into test group(n= 33)with 23 males and 10 females undergoing percentage dose schemes and control group(n=30)with 23 males and 7 females undergoing fixed dose schemes group in the process of narrowband ultraviolet B(NB-UVB)phototherapy.There was no statistical difference between two groups in age, gender and pre-treatment psoriasis area and severity index(PASI)score. Results After three weeks of treatment, the PASI score of test group(5.00±1.275)and control group(5.47±1.479)had no statistically significant difference in curative effect.After five weeks of treatment, compared with control group, the PASI score of test group was higher (1.73±1.626)vs(2.67±1.322), and the curative effect was better than control group. Conclusion In the two dose-increasing schemes of narrowband ultraviolet B(NB UVB)phototherapy for the treatment of psoriasis, percentage dose scheme is the prime choice in terms of efficacy.

     

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