Abstract: Objective To explore the preventive effect of rabeprazole and pantoprazole on gastrointestinal bleeding after PCI in acute coronary syndrome (ACS) patients with high bleeding risk and major adverse cardiovascular events (MACE). Methods Clinical data about 563 PCI postoperative patients who received dual antiplatelet therapy from March 2011 to June 2014 in the heart center of Navy General Hospital were retrospectively analyzed. Patients with high bleeding risks were divided into rabeprazole group, pantoprazole group and control group, gastrointestinal bleeding and MACE within 30 days after PCI were compared. Results There was no statistically significant difference in baseline characteristics and treatment after admission. The gastrointestinal bleeding rate of control group after PCI within 30 days (13 cases, 6.3%) were significantly higher than rabeprazole group (3 cases, 1.8%) and pantoprazole (4 cases, 2.1%)(P=0.028). There was no statistically significant difference between rabeprazole and pantoprazole group (P=1.000). The difference of total MACE rate was also not statistically significant (P=0.916). Conclusion Rabeprazole and pantoprazole can reduce the gastrointestinal bleeding of PCI postoperative patients with high bleeding risk, and it will not increase the occurrence of major adverse cardiovascular events in a short time.