1 484例过敏性疾病患者化学物质斑贴试验分析

Patch test results of 1 484 patients with allergic dermatitis

  • 摘要: 目的 探讨北京地区常见化学物质过敏原的种类,及其与性别、年龄、疾病的关系。 方法 对解放军总医院2013年6月- 2015年3月1 484例北京地区过敏性疾病患者进行斑贴试验并按性别、年龄和患病情况分组进行分析。 结果 1 484例北京地区患者化学品斑贴试验结果总阳性率45.4%,男性阳性率42.8%,女性阳性率46.9%,差异无统计学意义。北京地区最常见的致敏化合物为硫酸镍、氯化钴和重铬酸钾。氯化钴(P=0.031)、对苯二胺基质(P=0.012)、重铬酸钾(P=0.028)、硫酸镍(P=0.003)等化合物在不同年龄组的阳性率差异有统计学意义。硫酸镍(P=0.01)、Cl+Me-异噻唑(卡松CG)(P=0.008)等化合物在不同疾病组的阳性率差异有统计学意义。 结论 斑贴试验可以帮助患者明确过敏原,从而对疾病的防治提供依据;同时,由于试验结果在不同年龄组和不同疾病组阳性率存在差异,如氯化钴在青年组中斑贴试验的阳性率高于儿童组和老年人组,亚乙基二胺在湿疹组中斑贴试验阳性率明显高于其他各疾病组,且作为无创、安全的检验方法,斑贴试验可能对疾病的鉴别诊断提供帮助。

     

    Abstract: Objective To discuss the kinds of common allergens in Beijing area and its relationship between different genders, ages and diseases. Methods From June 2013 to March 2015, the patch test results of 1 484 patients with allergic diseases in Chinese PLA General Hospital were analyzed and grouped by gender, age and the types of dermatitis. Results Of the 1 484 cases, the total positive rate was 45.4%; In 568 male cases, the positive rate was 42.8%; In 916 female cases, the positive rate was 46.9%, with no statistically significant difference. The most common types of sensitization compounds in Beijing area were nickel sulfate, cobalt chloride and potassium dichromate. Among different age groups, the total positive rate of cobalt chloride (P=0.031), para-phenylene diamine matrix (P=0.012), potassium dichromate (P=0.028), nickel sulfate (P=0.003) had statistically significant difference. Among different groups of diseases, the total positive rate of nickel sulfate (P=0.01), Cl+Me- different thiazole (calzone CG) (P=0.008) also had statistically significant difference. Conclusion Patch test can help patients identify allergens, which can contribute to the prevention and control of the diseases; For example, cobalt chloride has a higher positive rate among adult groups, while ethylenediamine dihydrochloride has a higher positive rate in eczema patients. Meanwhile, as a noninvasiveness and safety method, patch test can probably contribute to the diagnosis of dermatitis.

     

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