Abstract: Objective To investigate the influential factors of early in-stent restenosis (ISR) in patients with coronary chronic total occlusion (CTO) after percutaneous coronary intervention (PCI). Methods Clinicaldata about 54 patients who had undergone coronary angiography (CAG) and implanteddrug-eluting stents (DES) with ISR in Chinese PLA General Hospital from November 2003 to July 2015 were analyzed retrospectively. All patients weredivided into two groups by time of ISR. The risk factors of ISR were analyzed by univariate analysis and multiple Logistic regression analysis. Results There were 76 ISR in 54 patients with CTO, with early ISR rate of 9.2% (7) and late ISR rate of 90.8% (69). Compared with late ISR group, the level of fibrinogen and uric acid (UA) in early ISR group was significantly higher (P=0.001, P=0.023), while the level of serum total bilirubin and serumdirect bilirubin was significantly lower (P=0.041, P=0.035). Multiple Logistic regression analysis showed fibrinogen OR=0.314, 95% CI (0.138-0.714)(P=0.006), uric acid (UA) OR=0.988, 95% CI (0.978-0.999) (P=0.028) and total bilirubin OR=1.453, 95% CI (1.113-1.896) (P=0.006) were independent predictors for early ISR after PCI. Conclusion Elevated fibrinogen level, elevated uric acid level, and low total bilirubin level are risk factors of early ISR after PCI.