Abstract: Objective To analyze clinical characteristics and risk factors for mortality of hospital-acquired Pseudomonas aeruginosa bloodstream infections and provide reference for clinical prevention and treatment. Methods Clinical characteristics and risk factors for mortality were analyzed retrospectively based on clinicaldata about patients with hospital-acquired pseuclomonas aeruginosa bloodstream infection in Chinese PLA General Hospital from January 2010 todecember 2014. Results A total of 136 patients were enrolled in this study, including 96 males and 40 females, of which, 130 patients (95.59%) had fever, 86 cases (63.24%) were with chills, 100 cases (73.52%) were with high or low white blood cell counts and 121 cases (88.97%) were with high level of C-reactive protein. A total of 32 patientsdied. Factors associated with mortality in univariate analysis included age> 70 years old, APACHEⅡ score, pulmonary infection, ICU admission, invasive mechanical ventilation, multipledrug resistance, hemoglobin< 90 g/L, and albumin< 35 g/L. Logistic regression analysis showed that high APACHEⅡ score and invasive mechanical ventilation were risk factors for mortality of bloodstream infection caused by Pseudomonas aeruginosa. Conclusion Fever, chill, abnormal white cell counts and high level of C-reactive protein are common features of Pseudomonas aeruginosa bacteremia bloodstream infection. High APACHE Ⅱ score and invasive mechanical ventilation are independent risk factors for mortality.