Abstract: Objective To explore the relationship between serum homocysteine (HCY) and high-sensitivity cardiac Troponin T (hsTnT) levels in a community elderly population. Methods The serum HCY and hsTnT levels were measured in Shougang community elderly population. There were 885 cases, including 367 men and 518 women, with age more than 60 years and average age of (69.2±6.3) years in Shijingshandistrict, Beijing, China. The elderly people weredivided into high HCY group (HCY≥15μmol/L) and normal HCY group (HCY< 15μmol/L), and the effects of HCY on hsTnT were analyzed. Results The level of hsTnT in high HCY group were significantly higher than normal HCY group (8.07±11.19) pg/dl vs (5.57±5.04) pg/dl, P< 0.001. Multiple logistic regression models showed that serum HCY was associated with hsTnT positively (OR: 1.77; 95% CI: 1.09 -2.89; P=0.022). Age, gender, SBP, dBP, FBG and smoking were independent factors of hsTnT. Conclusion Level of serum HCY is associated with hsTnT level in elderly population, which suggests that there is a relationship between HCY and subclinical myocardialdamage.