Abstract: Objective To explore the relationship between the mammographic appearances of breast infiltratingductal carcinoma and the expression of Ki-67 and p53. Methods The mammographic appearances of 189 patients with breast infiltrativeductal carcinoma confirmed by postoperative pathology in radiologydepartment of First Affiliated Hospital of Liaoning Medical University and The Fourth Hospital of Fushun Liaoning Province from August 2014 to September 2015 were retrospectively analyzed, and the relationships between mammographic appearances and postoperative pathological markers of Ki-67 and p53 were analyzed. Results The positive expression rate of Ki-67 in the obscured mass margin group was higher than circumscribed mass margin group and speculated mass margin group with statistically significantdifference (82.3% vs 67.9%, 63.9%, P< 0.05). The positive expression rate of p53 in irregular mass shape group was higher than oval mass shape group and lobular mass shape group (71.4% vs 65.5%, 51.7%), and it was higher in no lymph node metastasis group than lymph node metastasis group with statistically significantdifference (58.6% vs 40.9%, P< 0.05). Conclusion The mammographic appearances of obscured mass margin suggests high expression of Ki-67 in the tumor tissue, and irregular mass shape and no lymphatic metastasis suggests high expression of p53 in the tumor tissue.