Abstract: Objective To explore the supportive care needs and its influencing factors in cancer patients. Methods The 34-item short form Supportive Care Needs Survey (SCNS-SF34) was performed in 326 intermediate and advanced cancer patients who were hospitalized in our department from December 2014 to August 2015. A total of 321 effective questionnaires were taken back. Age of patients ranged from 22 to 86 (56.48 ±11.65) years old, 177 cases (55.1%) were men and 144 cases (44.9%) were women. Results The intermediate and advanced cancer patients supportive care needs of different dimension ranked from high to low as follows, health systems and information needs (2.67±0.99), physical and daily life needs (2.63±1.12), patient care and support needs (2.51±1.03), psychological needs (2.34±1.03) and sexual needs (1.39±0.79). Cancer patients physical and daily life needs and health systems and information needs were affected by gender, psychological and sexual needs by age, physical and daily life needs and psychological needs by pain and KPS score, sexual needs by final diagnosis time, and patients care and support needs and health systems and information needs by present types of treatment. Conclusion Intermediate and advanced cancer patients still have a great deal of unmet needs in health systems and information, physical and daily life, patient care and support, psychological needs and sexual domain. Gender, age, pain, KPS score, time of final diagnosis and present types of treatment are the influencing factors of cancer patients' needs. Patients should be supported by medical staff according to their different needs.