Abstract: Objective To explore the short-term clinical effecacy between laparoscopic assisted radical gastrectomy and open radical gastrectomy. Methods One hundred and eighty-five patients who were diagnosed with gastric cancer in our hospital from January to December in 2014 were enrolled in our study.There were 105 males and 80 females with average age of (55±6) years (ranging from 31 to 85 years).Of the 185 cases, 86 cases had undergone laparoscopic-assisted gastrectomy (laparoscopic group), and 99 cases with open radical gastrectomy (open group).The short-term clinical effecacy in these two groups was compared. Results There were significant differences in incision length (5.8±0.5) cm vs (14.1±1.3) cm, P< 0.05, suigical time (190.9±50.3) min vs (150.7±43.1) min, P< 0.05, intraoperative blood loss (107.3±70.3) ml vs (158.3±90.8) ml, P< 0.05, postoperative flatus time (3.0±0.4) d vs (3.9±0.5) d, P< 0.05, feeding time (3.7±0.9) d vs (4.3±0.7) d, P< 0.05 and hospital stay (9.6±3.4) d vs (12.2±6.9) d, P< 0.05 between two groups.However, there were no significant differences in the number of resected lymph nodes (26.4±7.5) vs (27.2±7.7), P> 0.05, number of positive lymph nodes (3.0±1.0) vs (3.0±0.9), P> 0.05, positive margin rate (1.16% vs 1.01%, P> 0.05) and the incidence of postoperative complications (4.6% vs 5.0%, P> 0.05) between two groups. Conclusion Traditional open radical gastrectomy surgery can remove the lesion completely, but it has larger incision, larger amount of bleeding and longer postoperative recovery time.Laparoscopy assisted radical gastrectomy with smaller surgical trauma, faster recovery can achieve better short-term clinical results with a clear advantage, but its surgical time is longer than traditional open radical gastrectomy surgery.