Abstract: Objective To analyze the short and medium term outcome of the reconstruction and revascularization for diffuse coronary artery disease by coronary artery bypass grafting (CABG) plus repair with a patch across the stenosis. Methods Clinical data about 34 patients who underwent coronary artery reconstruction and bypass graft by repair with a patch across the stenosis (reconstruction group) in Chinese PLA General Hospital from January 2013 to June 2015 were retrospectively analyzed. Another 132 patient who underwent conventional CABG during the same period were selected as conventional group. The number of bypass grafts, cardiopulmonary bypass (CPB) time, aortic cross-clamping time, operative death, perioperative complications and patency rate, survival rate and the rate of MACCE were investigated and compared between two groups. Results There were no significant differences in perioperative mortality and incidence of complications between two groups. All cases were followed up in reconstruction group, one case died, and one case had cerebrovascular complication. Thirty-three patients received coronary artery CT angiography, no occlusion was found in IMA graft, and one SVG graft had occlusion. One hundred and twenty-four cases (94.0%) were followed up in conventional group. Four cases died including one case of cardiac death and one case of recurrence of MI. Eight cases had cerebrovascular complications. Ninety-seven patients received coronary artery CT angiography, one IMA graft and four SVG graft occlusion were found. The survival rate, incidence of MACCE and patency rate did not differ significantly between two groups. Conclusion Reconstruction and revascularization for diffuse coronary lesion by CABG plus repair with a patch across the stenosis is safe with excellent short and medium term outcome. This surgical technique is a useful option of revascularization for patients with diffuse coronary artery disease.