Abstract: Objective To investigate the correlation between degrees of nonalcoholic fatty liver disease (NAFLD) and left ventricula systolic function in patients with type 2 diabetes mellitus. Methods The study was performed in 200 patients with type 2 diabete who underwent liver ultrasonography, echocardiography and blood test in the First Affiliated Hospital of Liaoning Medical University from March to August in 2015. All participants were divided into two groups: patients without ultrasound-diagnosed NAFLD (group A, n=94) and patients with ultrasound-diagnosed NAFLD (group B, n=106) according to the results of liver ultrasound. Then, patient in group B were graded as mild (group B1, n=45), moderate (group B2, n=31), and severe (group B3, n=30). Information of fasting blood-glucose, triglyceride, low density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT), aspartate aminotransferas (AST), left ventricular diastolic diameter (LVDD), left ventricular systolic diameter (LVSD), stroke volume (SV), left ventricula ejection fraction (LVEF), left ventricular fractional shortening (LVFS) were collected and analyzed. Results Patients in group B were more likely to be overweight/obese and had higher level of fasting blood-glucose, triglyceride, ALT, AST, LDL-C, LVSD (P＜ 0.05) and lower level of SV, LVEF, LVFS (P＜ 0.01) than those in group A. The possibility of patients in group B1, B2 and B3 who were more likely to be overweight/obese and had higher level of fasting blood-glucose, triglyceride, ALT, AST, LDL-C (P＜ 0.05 and lower level of SV, LVEF, LVFS (P＜ 0.05) was group B3＞ group B2＞ group B1. Conclusion The severity of NAFLD i negatively correlated with left ventricular systolic function in patients with type 2 diabetes mellitus.