Abstract: Objective To explore clinical features of obscuregastrointestinal bleeding (OGIB) by capsule endoscopy (CE) and factors associated with rebleeding. Methods One hundred and eighty-seven patients with OGIB who had undergone CE in our hospital from January 2012 to June 2015 were selected and divided into two groups including positive group ( group P, n=80) and negative group ( group N, n=107), and the latter group was divided into two sub groups including negative rebleeding group ( group NR, n=18) and negative non-rebleeding group ( group NNR, n=89).Their clinical data, including age, gender, complications, history of smoking and drinking, lowest level of Hb, intervals from onset to examination, bleeding times before examination, types of hemorrhage, hypotension and blood transfusion volume before examination and rebleeding, were collected. Results The positive diagnostic rate examined by CE was 42.8%.The age, proportion of NSAIDs use, hypotension, overt bleeding, rebleeding and median volume of transfusion before CE of group P were older, higher or longer than group N (65.4±13.2) years vs (61.3±17.4) years, 18.8% vs 7.5%, 36.6% vs 18.7%, 42.5% vs 27.1%, 31.3% vs 27.1%, 600 ml vs 200 ml.Median interval from bleeding to CE examination of group P was short than group N (11 d vs 25 d).The proportion of comorbidities, warfarin therapy, multiplex rebleeding before CE, and median volume of transfusion of group NR were higher or longer than group N (61.1% vs 27.0%, 33.3% vs 4.5%, 77.7% vs 48.2%, 400 ml vs 200 ml). Conclusion Older age, NSAIDs use, a relatively short time from bleeding to CE, hypotension and transfusion before CE and overt bleeding may result in positive CE findings.The comorbidities, warfarin therapy, multiple multiplex rebleeding before CE, and volume of transfusion have important clinical values for predicting rebleeding in patients with negative CE findings.