Abstract: Objective To investigate the clinical features of pulmonary sequestration(PS). Methods Clinical data and imaging characteristics of 49 patients diagnosed with pulmonary sequestration who admitted to Chinese PLA General Hospital from July 2008 to May 2016 were retrospectively analyzed. Results Of the 49 cases, there were 25 males and 24 females with no specificity in clinical symptom.The duration from onset to diagnosis was 5 d to more than 10 years with average time of 14.23 months and median time of 4 months.Forty-seven patients underwent contrast enhanced CT, and solid or cystic lesion could be found.Lung lesion receiving blood supply from an anomalous systemic artery was the diagnostic criterion. Conclusion Pulomonary sequestration should be taken into account in patients with repeatedly cough, expectoration and fever after anti-infection treatment and solid or cystic lesion in CT image.Contrast enhanced CT/MRI is helpful in PS diagnosis.