Abstract: Objective To evaluate the role of low dose tranexamic acid in reducing allogenic blood transfusion in total hip replacement surgery. Methods One hundred and eighty-one patients who underwent total hip replacement from January 2013 to June 2015 in our hospital were enrolled in this study, and they were divided into TXA group(n=88) and control group(n=93) according to the usage of TXA.The indexes, including pre-or postoperative Hb, fall in Hb, mean unit of allogeneic red blood cells transfusion, intraoperative blood loss, postoperative drainage, were compared between two groups. Results There were no significant differences in preoperative Hb(P=0.850), intraoperative blood loss(P=0.072), postoperative drainage(P=0.214), and mean unit of allogeneic red blood cells transfusion(P=0.091) between two groups.While, there were significant differences in postoperative HbTXA group:(125.65±39.02) g/L vs control group:(112.08±15.44) g/L, and fall in HbTXA group:(3.55±35.41) g/L vs control group:(16.59±14.19) g/L. Conclusion Using of low dose tranexamic acid is effective in reducing the fall of postoperative Hb, while it cannot reduce the requirement of allogenic blood transfusion in total hip replacement surgery.