B10细胞在器官移植术后免疫耐受中的研究现状和前景

Status quo and prospect of research on B10 cell in immune tolerance after organ transplantation

摘要: 器官移植术后的理想目标是达到移植物的免疫耐受状态，相关研究显示调节性B细胞（regulatory B cells，Bregs）在诱导器官移植术后免疫耐受中有积极作用，但起主导作用的细胞表型和具体机制尚无共识。近年来B10细胞的发现进一步揭示了调节性B细胞诱导器官移植术后免疫耐受的相关机制，并有望最终诱导免疫耐受状态。本文就B10细胞的研究现状及其在器官移植免疫耐受中的作用、前景进行综述。

Abstract: Immune tolerance is the ideal goal for organ transplantation.Related research shows regulatory B cells play an active role in immune tolerance after organ transplantation, but the cell phenotype and specific mechanism of regulatory B cells are still uncertain.In recent years, the discovery of B10 cells further reveals the mechanism of regulatory B cell in immune tolerance after organ transplantation.This article reviews recent researches on B10 cells and its role in immune tolerance after organ transplantation.