Abstract: Molecular markers have unique advantages on disease diagnosis, prediction of prognosis and assessment of therapeutic reactions, and it also becomes a hot topic in the area of breast cancer.Except for the well-known breast cancer biomarkers ER, PR and HER2, in recent years, many potential biomarkers for breast cancer have been found, including epidermal growth factor receptor(EGFR), vascular endothelial growth factor(VEGF), Ki67, androgen receptor(AR), PI3K/AKT/mTOR signaling pathway, poly ADP-ribose polymerase 1(PARP-1), as well as long chain noncoding RNA(lncRNAs).With the approaching of precision medicine, molecular markers of breast cancer shows important guiding significance for personalised therapy.