Abstract: Objective To observe the clinical effecacy of GnRH-a in the prevention of recurrence of uterine myoma after laparoscopic myomectomy. Methods Patients admitted to our hospital from June 2012 to June 2014 with uterine myoma were selected, of which 82 cases were performed laparoscopic myomectomy. All the 82 patients were divided into the observation group (GnRH-a treatment group, 33 cases) and control group (simple operation group, 49 cases), respectively. The uterine volume changes and postoperative recurrence of the two groups were compared. Results The difference of general data between the two groups was not signifcant. Uterine volumes in observation group were less than those in control group at 6 months (64.1±19.6 vs 80.3±27.2) cm³, 12 months (59.0±23.7 vs 83.7±28.8) cm³, 18 months (62.9±24.3 vs 88.2±32.3) cm³and 24 months (66.7±27.1 vs 95.6±34.9) cm³, with statistically signifcant differences (P< 0.001, respectively). Postoperative recurrence rate of observation group were lower than those of control group at 18 months (6.1% vs 22.4%, P=0.046) and 24 months (9.1% vs 30.6%, P=0.021) after operation, respectively. Conclusion GnRH-a can reduce uterine volume and recurrence in patients with uterine myoma after laparoscopic myomectomy.