Abstract: Objective To analyze the factors impacting postoperative prognosis of the primary small intestinal stromal tumor (SIST). Methods Clinical data about patients with resectable SIST admitted to the General Hospital of the Air Force from December 2007 to December 2015 were collected retrospectively, and univariate analysis were utilized to identify the clinicopathological indicators of disease free survival in resectable SIST. Results Total of 47 patients were followed up for a median of 33.5(2-102) months, 9(19.15%) patients suffered metastasis, 3(6.39%) recurred, and 7(14.90%) died. The mean interval between the surgery and recurrence or death was 18 months or 33.8 months, respectively. The 1, 3, 5-year disease-free survival rates after surgery were 86.1%, 82.4%, 73.2%, respectively, while the 1, 3, 5-year overall survival rates were 91.0%, 85.3%, 76.3%, respectively. The tumor rupture, tumor mitotic and tumor location were prognostic factors for tumor recurrence in SIST (P< 0.05). Conclusion Tumor rupture, tumor mitotic and tumor location are probably related with tumor metastasis and recurrence in SIST.