Abstract: The incidence of prostate cancer increased year by year in the world.Bone is the main target of metastasis of prostate cancer, which is closely related to prognosis. The mechanism of bone metastasis is revealed by some signaling pathways and provides ideas and guidance for clinical treatment. This review summarizes the signaling pathways associated with bone metastasis in prostate cancer, including MET and VEGF signaling pathway, beta 2- adrenergic signaling pathway, androgen receptor signaling pathway and RANKL signaling pathway.In this review, the role and mechanism of these pathways in bone metastases are elucidated and the application of related research results in clinical treatment are also introduced.