叶黄素对白内障术后患者黄斑及视觉功能的影响

Effects of lutein on the macular and visual function after cataract surgery in the elderly

  • 摘要: 目的 探讨预防性应用叶黄素对老年性白内障患者术后视觉功能的影响。 方法 选择2014年1-10月老年性白内障择期手术患者80例,其中男性52例,女性28例,年龄55 ~ 75岁。所有患者先行晶状体超声乳化联合人工晶状体植入术。将术后患者随机均分为A、B两组,每组40例。A组为实验组,于术后第1天给予叶黄素口服,12 mg/d,1次/d;B组为安慰剂对照组,同时间点给予淀粉口服,12 mg/d,1次/d,两组均连续服用3个月。于术后研究开始前(T0),研究开始后1个月(T1)、3个月(T2)、6个月(T3)、12个月(T4)时记录所有患者最佳矫正视力,视功能评分,黄斑色素密度值(MPOD)及术后相关并发症,进行统计分析。 结果 在T1 ~ T4时,A组最佳矫正视力均显著高于B组(T1:0.93±0.21 vs 0.84±0.19;T2:0.93±0.20 vs 0.83±0.20;T3:0.92±0.17 vs 0.80±0.18;T4:0.87±0.21 vs 0.76±0.22)(P均<0.05);A组视功能评分均显著高于B组(T1:88.0±3.19 vs 85.9±14.09;T2:86.1±2.55 vs 82.91±4.24;T3:83.1±13.11 vs 79.21±4.93;T4:79.9±4.37 vs 75.3±5.73)(P均<0,05),黄斑色素密度值也高于B组(T1:0.578±0.086 vs 0.535±0.097;T2:0.591±0.089 vs 0.520±0.088;T3:0.585±0.091 vs 0.508±0.084;T4:0.574±0.074 vs 0.486±0.070)(P均<0.05)。。两组术后早期并发症发生率无统计学差异(P>0.05)。 结论 白内障术后预防性应用叶黄素,可有效改善黄斑色素密度,保护患者视觉功能。

     

    Abstract: Objective To explore the effects of lutein on the macular and visual function after cataract surgery in the elderly. Methods Total of 80 patients with senile cataract including 52 males and 28 females with an average age of 55-75 years old were selected and randomly divided into group A(experiment group, n=40, postoperatively treated with lutein, 12 mg/d, once a day for 3 months) and group B (control group, n=40, postoperatively treated with starch as placebo, 12 mg/d, once a day for 3 months). All the patients underwent phacoemulsification plus intraocular lens implantation before the experiment. At T0 (before experiment), T1 (1 month after experiment), T2 (3 months), T3 (6 months) and T4 (12 months), the best-corrected visual acuity (BCVA), visual function index (VF value) and macular pigment density values (MPOD) were collected. Results The BCVA, VF value and MPOD In group A at T1-T4 were respectively higher than those in group BBCVA (T1:0.93±0.21 vs 0.84±0.19; T2:0.93±0.20 vs 0.83±0.20; T3:0.92±0.17 vs 0.80±0.18; T4:0.87±0.21 vs 0.76±0.22)(P< 0.05, respectively). VF value (T1:88.0±3.19 vs 85.9±14.09; T2:86.1±2.55 vs 82.9±4.24; T3:83.1±3.11 vs 79.2±4.93; T4:79.9±4.37 vs 75.3±15.73) (P< 0.05, respectiely). MPOD (T1:0.578±0.086 vs O.535±0.097; T2:0.591±0.089 vs 0.520±0.088; T3:0.585±0.091 vs 0.508±0.084; T4:0.574±0.074 vs 0.486±0.070)(P< 0.05, respectively). No significant difference was deceted between the two groups in early postoperative complications. Conclusion Prophylactic usage with lutein after cataract surgery may improve the macular and visual function of elderly.

     

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