Prevalence of serum high density lipoprotein cholesterol in healthy Han Chinese subjects in Urumqi Xinjiang Uygur Autonomous Region
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摘要: 目的 调查乌鲁木齐市汉族健康体检人群的高密度脂蛋白水平。 方法 回顾性分析35 017例健康体检者的查体资料，剔除肝功能受损、血糖异常、肾损伤等患病人群资料，剩余22 643例，其中男性10 265例，女性12 378例。依据年龄划分为6组，使用匀相法检测血清高密度脂蛋白胆固醇(high density lipoprotein cholesterol，HDL-C)水平。 结果 整体人群中血清HDL-C为(1.42±0.33) mmoL/L，高于1.30 mmol/L的全国平均水平。血清HDL-C水平男女差异较大，女性血清HDL-C中位数1.51 mmol/L，显著高于男性的1.24 mmol/L (χ2=27 295.33，P<0.001)。男性60岁以上年龄组较低龄组HDL-C水平更高(P<0.01)；女性18 ～ 29岁年龄组较30 ～ 39岁年龄组、40 ～ 49岁年龄组、50 ～ 59岁年龄组HDL-C水平低(P<0.01)，中位数水平由18 ～ 29岁年龄组的1.54 mmol/L降低至≥70岁年龄组的1.49 mmol/L (P均<0.01)。依据2007年中国血脂异常防治指南，本组健康体检人群中10.71%(2 425/22 643)的个体<1.04 mmol/L，男性异常检出率高达18.80%(1 930/10 265)。不同年龄段、不同性别之间HDL-C异常差异均有统计学意义，且同一年龄段中，男性HDL-C异常的比例高于女性(P均<0.01)。 结论 新疆乌鲁木齐市地区血清HDL-C水平高于全国平均水平，男性低高密度脂蛋白胆固醇异常检出率较高，年轻女性HDL-C水平在所有年龄组中最高。Abstract: Objective To investigate the prevalence of high density lipoprotein (HDL) in healthy Han Chinese subjects in Urumqi. Methods Health screening data of 35 017 cases were retrospectively collected, and people with liver dysfunction, abnormal blood glucose, renal dysfunction were excluded. A total of 22 643 cases(10 265 males, 12 378 females) were enrolled in and divided into 6 groups according to age. Serum high density lipoprotein cholesterol (high density lipoprotein, HDL-C) was detected using homogeneous method. Results Overall serum HDL-C was (1.42±0.33) mmol/L in our investigation, higher than national average of 1.30 mmol/L. Female had higher serum HDL-C level than male (1.51 mmol/L vs 1.24 mmol/L, P< 0.001). In male, serum HDL-C was higher in those aged over 60 years (60-69 group:1.28(1.10, 1.47); ≥ 70 group:1.30(1.11, 1.51)) than those in other age groups (30-39 group:1.22 (1.07, 1.39); 40-49 group:1.22 (1.06, 1.41); 50-59 group:1.23 (1.07, 1.41)) (P < 0.01, respectively). In opposite, youngest female group aged 18-29 had highest level of HDL-C[1.54 (1.36, 1.75)] as compared with other age groups (P < 0.01, respectively). According to the guideline of prevention and treatment of dyslipidemia in China in 2007, 10.71% (2 425/22 643) of healthy subjects had low HDL-C (< 1.04 mmol/L), and the incidence was higher in male (18.80%, 1 930/10 265) than in female (4.00%, 495/12 378). This trend was also testified in the comparison between male and female in each age group. Conclusion The serum level of HDL-C of Chinese Han subjects in our study in Urumqi city is higher than the average level of Chinese adults. The percentage of low HDL-C was higher in male, and youngest female group has in highest HDL-C level.
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