Abstract: Objective To investigate the effect of hyperbaric oxygen therapy combined with traditional treatment on the recovery of patients with spinal cord injury. Methods Total of 76 patients with spinal cord injury admitted in our hospital from Jan 2015 to Jan 2016 were randomly divided into treatment group (n=38) and control group (n=38), and both groups were given routine treatment and rehabilitation physical therapy, while the treatment group patients received additional hyperbaric oxygen therapy at the same time.After three months treatment, the independent ability, the function of exercise and activities of daily life were examined by Function Independent Measure(FIM) and Barthel Index(BI), respectively, and the spinal function was measured by ASIA International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI). Results After three months treatment, FIM (90±13.76 vs 79±12.19) and BI (71±13.72 vs 59±11.28)in treatment group were significantly higher than those in control group (P < 0.05, respectively). Moreover, the sensory function(190.65±18.26 vs 132.78±17.63, P < 0.05)and motor function (68.56±17.43 vs 50.84±15.71, P < 0.05) in patients undergoing hyperbaric oxygen therapy were also greater than those in control group. Conclusion The hyperbaric oxygen therapy combined with routine rehabilitation physical therapy can significantly improve the recovery of sensory and motor function of patients with spinal cord injury, and then facilitates the recovery of the patient's independent ability and activities of daily life.