Abstract: Objective To explore the role of¹⁸F-FDG PET-MR in diagnosis of pancreatic ductal adenocarcinoma (PDAC). Methods The¹⁸F-FDG PET-MR features of suspected PDAC in Chinese PLA General Hospital from February 2013 to April 2014 were retrospectively analyzed, and their imaging characteristics were summarized and compared to the pathological results. Results Of the 12 suspected PDAC patients, 8 patients were diagnosed as PDAC, 2 were pancreatic neuroendocrine tumors, 1 IPMN and 1 chronic pancreatitis, based on the PET-MR image.The diagnostic imaging findings of 11 patients matched with the pathological results.Only 1 case with peripancreatic lymph node tuberculosis was misdiagnosed as pancreatic cancer.Of the 7 PDAC patients, head of pancreas was involved in 5 cases, neck of pancreas involved in 1 case, and tail of pancreas involved in 1 case.The mean maximum diameter of the tumor was (4.1±0.9) cm and the mean SUV_maxwas 5.07±1.92.The dilation of pancreatic duct was found in 5 cases, 3 cases showed the dilation of bile duct, and several metastases in liver were found in 1 case.Accumulation of radioactivity could be found in all lesions. Conclusion ¹⁸F-FDG PET-MR can accurately reveal the distribution, morphology and metabolism of the lesion of PDAC.The image findings show speci ficity and are helpful to the diagnosis and differential diagnosis of pancreatic cancer.